Defines standards for, and mandates, Federal publishing of documents and data in machine-readable and nonproprietary formats.

Reauthorizes programs under the Public Health Service Act and the Federal Food, Drug, and Cosmetic Act to address public health security and all-hazards preparedness and response, including those related to antimicrobial resistance and genomic engineering technologies.

Promotes the use of stem cells for research purposes.

Establishes guidelines to implement Extreme Risk Protection Orders to temporary limit access to firearms for some individuals based on a number of factors including evidence of a serious mental illness, among others.

Mandates a study to better understand the incidence of veterans who died by suicide, violent death, or accidental death, as well as a list of prescribed medications, legal or illegal substances, and medical diagnoses.

Loosens federal restrictions regarding the production, possession, distribution, dispensation, administration, laboratory testing, recommending use, and delivery of medical marijuana and cannabidiol.

Encourages development of commercial advanced nuclear reactor facilities through streamlined NRC licensing process

Amends the Public Health Service Act to expand funding for activities related to Alzheimer’s disease, cognitive decline, and general brain health.

Specifies and addresses gaps or inconsistencies regarding best practices for chronic and acute pain management, and provides updates and recommendations to those practices.

Preliminary step toward proceeding with leasing portion of the Arctic National Wildlife Reserve for oil and gas development.

Revises downwards estimate of benefits from 2012 Mercury Air Toxics Rule, and proposes to determine that it is not “appropriate and necessary” to regulate hazardous air pollutants, including mercury, emitted from power plants  

Revises September 2016 safety rules to undo requirements assessed by current Administration as "unduly burdensome" for oil and gas producers.