Original Development Brief – Prohibits further extension of the requirement to implement positive train control beyond December 31, 2018.

Proposes that certain power plants be offered new pricing dependent on their "resiliency" — defined by having a 90 day supply of fuel on-site —  which FERC later rejects.

Rescinds Obama administration rule that required hydraulic fracturing ("fracking") operators on Federal and Indian Lands to adhere to certain monitoring and reporting requirements.

Provides guidance for industry on the development of human drug products in which a nanomaterial is present in the final dosage form. 

Requires the Department of Commerce to establish the Federal Advisory Committee on the Development and Implementation of Artificial Intelligence.

Expands the ability of workplace wellness programs to collect personalized genetic information from employees but still remain in compliance with the Genetic Information Nondiscrimination Act, the American Disabilities Act, and the Public Health Service Act.

Strengthens border security and increases resources for enforcement of immigration laws.

Supports and provides a regulatory framework for manufacturer development of autonomous vehicle technology.

Modernizes and strengthens the United States anti-money laundering and counter-terrorism financing regime.

Revises regulations regarding the importation, interstate movement, and environmental release of certain genetically engineered organisms.

The Code Like a Girl Act directs the National Science Foundation (NSF) to award competitive grants to institutions of higher education, local educational agencies, or nonprofit organizations to accelerate research efforts to increase understanding of the factors that contribute to the willingness or unwillingness of girls under the age of 11 to participate in STEM (science, technology, engineering, and mathematics, including computer science) activities.

Proposes to repeal the Obama-era Clean Power Plan over concerns about EPA jurisdiction, regulatory overreach, and harm to the coal industry.