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September 26, 2017 8:15 am

Workshop: NIH Workshop on Translational Challenges of Induced Pluripotent Stem Cells

  • Government
  • Agency
  • Genetics/Genomics

The discovery of induced pluripotent stem cells (iPSCs) over a decade ago has transformed stem cell biology and biomedical research, ranging from disease modeling, drug discovery and predictive toxicology to regenerative medicine applications. To bring iPSC-based therapies more efficiently to patients, it is pivotal to continue addressing the key knowledge gaps and roadblocks in a coordinated multidisciplinary fashion. This workshop, hosted by NCATS, will focus on defining collaborative opportunities, addressing challenges and applying best practices in translational iPSC research. Topics of interest are quality control standards for pluripotency, safety, experimental reproducibility, cost-efficient scalability and manufacturing, improved and efficient differentiation protocols, advances in -omics and functional characterization of cell type identities, and other relevant questions. As a deliverable of the workshop, the gathered information and recommendations will be used to draft a white paper for the translational stem cell community.

Goals for the workshop include:

  • Highlighting the biological and technological challenges of advancing iPSCs into clinical applications and drug discovery;
  • Evaluating the state-of-the field of iPSC translation and discussing critical steps for quality control, standardization and reproducibility;
  • Discussing methods of protocol development/optimization and molecular and functional analyses; and
  • Seeking input from experts on areas of prioritization and tractable strategies for the iPSC field. 

This information is derived from the NCATS announcement, where more information, including links to the website, agenda, and registration.